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Amino acid derivatives of phenothiazine scaffold were synthesized and screened for their anticonvulsants activity against chemo shock induced screening to study the mechanism of action of anticonvulsants. Strychnine, thiosemicarbazide and 4-aminopyridine were used for induction of seizures. Rotorod test was used to study the neurotoxicity profile of these compounds. All these compounds protected against strychnine and thiosemicarbazide (20 mg/kg) induced seizures at a dose of 30 mg/kg up to 2 h. In case of 4-aminopyridine (13.3 mg/kg) induced seizure, protection was observed only up to 15 minute which was followed by death of the animals.

Synthesis and Anticonvulsant Activity (Chemo Shock) of Phenothiazine Amino Acid Derivatives