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A series of novel 2-(4-substituted-piperazinyl-methyl)-3-(N-isonicotinamide-yl)-quinazoline- 4-one 4a-l were designed, synthesized, characterized and evaluated for in vitro antitubercular, antibacterial and antifungal activity. Compounds 4f , 4h and 4l exhibited excellent antitubercular activity against mycobacterium tuberculosis H 37 Rv .

Novel Piperazinyl-Quinazoline-4-one Analogs: Design, Synthesis and Evaluation of In Vitro Biological Activity