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We present a novel model to estimate biological effects caused by artificialradiation exposure, Whack-a-mole (WAM) model. It is important to take accountof the recovery effects during the time course of the cellular reactions. Theinclusion of the dose-rate dependence is essential in the risk estimation oflow dose radiation, while nearly all the existing theoretical models relies onthe total dose dependence only. By analyzing the experimental data of therelation between the radiation dose and the induced mutation frequency of 5organisms, mouse, drosophila, chrysanthemum, maize and tradescantia, we foundthat all the data can be reproduced by WAM model. Most remarkably, a scalingfunction, which is derived from WAM model, consistently accounts for theobserved mutation frequencies of 5 organisms. This is the first rationale toaccount for the dose rate dependence as well as to give a unified understandingof a general feature of organisms.

Whack-A-Mole Model: Towards unified description of biological effect caused by radiation-exposure