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We propose LD(Low Dose) model, the extension of LDM model which was proposedin the previous paper [Y. Manabe et al.: J. Phys. Soc. Jpn. 81 (2012) 104004]to estimate biological damage caused by irradiation. LD model takes account ofall the considerable effects including cell death effect as well asproliferation, apoptosis, repair. As a typical example of estimation, we applyLD model to the experiment of mutation frequency on the responses induced bythe exposure to low levels of ionizing radiation. The most famous and extensiveexperiments are those summarized by Russell and Kelly [Russell, W. L. & Kelly,E. M: Proc. Natl Acad. Sci. USA 79 (1982) 539-541], which are known as'Mega-mouse project'. This provides us with important information of thefrequencies of transmitted specific-locus mutations induced in mousespermatogonia stem-cells. It is found that the numerical results of themutation frequency of mice are in reasonable agreement with the experimentaldata: the LD model reproduces the total dose and dose rate dependence of datareasonably. In order to see such dose-rate dependence more explicitly, weintroduce the dose-rate effectiveness factor (DREF). This represents a sort ofpreventable effects such as repair, apoptosis and death of broken cells, whichare to be competitive with proliferation effect of broken cells induced byirradiation.

Comparison of data on Mutation Frequencies of Mice Caused by Radiation - Low Dose Model -