English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

*Uggen, C W; *Dines, J; **Uggen J C; **Mason, J; **Razzano, P; *Dines, D; +**Grande D A *Dept. of Orthopaedic Surgery, North Shore/ LIJ Health System, New Hyde Park, NY +**North Shore/ LIJ Research Institute, Manhasset, NY dgrande@nshs.edu Introduction: Rotator cuff tears are a common soft tissue injury of the musculoskeletal system. These tears heal by formation of inferior repair tissue, which may lead to severe joint dysfunction. A controversy exists over whether rotator cuff tendons heal after surgery. The endogenous healing is poor or insufficient in most rotator cuff tears and especially in large tears. A method for augmenting the endogenous healing process could be of significant clinical value. The specific aim of this study was to determine if local delivery of an anabolic growth factor using a novel, combined tissue engineering gene therapy approach results in improved healing of rotator cuff tendon defects compared to suture repaired controls. This study contained two-phases; the in vitro phase demonstrated the feasibility of using a tissue engineered gene therapy platform for tendon repair. Rat tendon fibroblasts (RTFs) were transduced with either platelet-derived growth factor[PDGF] or insulin like growth factor-1 [IGF-1]. Confirmation of active peptide was assessed, and then ability of the peptide to up regulate metabolism in an adjacent, local environment was demonstrated. The in vivo phase evaluated a new cell-polymer construct with RTFs transduced with PDGFor IGF-1 genes for its ability to augment tendon repair in a rat tendon fibroblast (RTF) model of rotator cuff injury.

Tendon Gene Therapy Modulates the Local Repair Environment in the Shoulder