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Iron is essential for survival of most organisms. All organisms have thus developed mechanisms to sense, acquire and sequester iron. In  C. elegan s, iron uptake and sequestration are regulated by HIF-1. We previously showed that  hif-1  mutants are developmentally delayed when grown under iron limitation. Here we identify  nhr-14 , encoding a nuclear receptor, in a screen conducted for mutations that rescue the developmental delay of  hif-1  mutants under iron limitation.  nhr-14  loss upregulates the intestinal metal transporter SMF-3 to increase iron uptake in  hif-1  mutants.  nhr-14  mutants display increased expression of innate immune genes and DAF-16/FoxO-Class II genes, and enhanced resistance to  Pseudomonas aeruginosa . These responses are dependent on the transcription factor PQM-1, which localizes to intestinal cell nuclei in  nhr-14  mutants. Our data reveal how  C. elegans  utilizes nuclear receptors to regulate innate immunity and iron availability, and show iron sequestration as a component of the innate immune response.

NHR-14 loss of function couples intestinal iron uptake with innate immunity in C. elegans through PQM-1 signaling