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Intracellular parasitism often results in gene loss, genome reduction, and dependence upon the host for cellular functioning. Rozellomycota is a clade comprising many such parasites and is related to the diverse, highly reduced, animal parasites, Microsporidia. We sequenced the nuclear and mitochondrial genomes of  Paramicrosporidium saccamoebae  [Rozellomycota], an intranuclear parasite of amoebae. A canonical fungal mitochondrial genome was recovered from  P. saccamoebae  that encodes genes necessary for the complete oxidative phosphorylation pathway including Complex I, differentiating it from most endoparasites including its sequenced relatives in Rozellomycota and Microsporidia. Comparative analysis revealed that  P. saccamoebae  shares more gene content with distantly related Fungi than with its closest relatives, suggesting that genome evolution in Rozellomycota and Microsporidia has been affected by repeated and independent gene losses, possibly as a result of variation in parasitic strategies (e.g. host and subcellular localization) or due to multiple transitions to parasitism.

The genome of an intranuclear parasite, Paramicrosporidium saccamoebae , reveals alternative adaptations to obligate intracellular parasitism