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Aging stem cells lose the capacity to properly respond to injury and regenerate their residing tissues. Here, we utilized the ability of  Drosophila melanogaster  germline stem cells (GSCs) to survive exposure to low doses of ionizing radiation (IR) as a model of adult stem cell injury and identified a regeneration defect in aging GSCs: while aging GSCs survive exposure to IR, they fail to reenter the cell cycle and regenerate the germline in a timely manner. Mechanistically, we identify  foxo  and mTOR homologue,  Tor  as important regulators of GSC quiescence following exposure to ionizing radiation.  foxo  is required for entry in quiescence, while  Tor  is essential for cell cycle reentry. Importantly, we further show that the lack of regeneration in aging germ line stem cells after IR can be rescued by loss of  foxo .

Loss of foxo rescues stem cell aging in Drosophila germ line