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The  Reproducibility Project: Cancer Biology  seeks to address growing concerns about reproducibility in scientific research by conducting replications of selected experiments from a number of high-profile papers in the field of cancer biology. The papers, which were published between 2010 and 2012, were selected on the basis of  citations and Altmetric scores  ( Errington et al., 2014 ). This Registered Report describes the proposed replication plan of key experiments from ' Fusobacterium nucleatum  infection is prevalent in human colorectal carcinoma' by Castellarin and colleagues published in  Genome Research  in 2012 ( Castellarin et al., 2012 ). The experiment to be replicated is reported in Figure 2. Here, Castellarin and colleagues performed a metagenomic analysis of colorectal carcinoma (CRC) to identify potential associations between inflammatory microorganisms and gastrointestinal cancers. They conducted quantitative real-time PCR on genomic DNA isolated from tumor and matched normal biopsies from a patient cohort and found that the overall abundance of  Fusobacterium  was 415 times greater in CRC versus adjacent normal tissue. These results confirmed earlier studies and provide evidence for a link between tissue-associated bacteria and tumorigenesis. The Reproducibility Project: Cancer Biology is a collaboration between the  Center for Open Science  and  Science Exchange  and the results of the replications will be published in  eLife .

Registered report: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma