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Formation of the  Drosophila  adult abdomen involves a process of tissue replacement in which larval epidermal cells are replaced by adult cells. The progenitors of the adult epidermis are specified during embryogenesis and, unlike the imaginal discs that make up the thoracic and head segments, they remain quiescent during larval development. During pupal development, the abdominal histoblast cells proliferate and migrate to replace the larval epidermis. Here, we provide evidence that the microRNA,  miR-965 , acts via  string  and  wingless  to control histoblast proliferation and migration. Ecdysone signaling downregulates  miR-965  at the onset of pupariation, linking activation of the histoblast nests to the hormonal control of metamorphosis. Replacement of the larval epidermis by adult epidermal progenitors involves regulation of both cell-intrinsic events and cell communication. By regulating both cell proliferation and cell migration,  miR-965  contributes to the robustness of this morphogenetic system.

miR-965 controls cell proliferation and migration during tissue morphogenesis in the Drosophila abdomen