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The  Reproducibility Project: Cancer Biology  seeks to address growing concerns about reproducibility in scientific research by conducting replications of selected experiments from a number of high-profile papers in the field of cancer biology. The papers, which were published between 2010 and 2012, were selected on the basis of  citations and Altmetric scores  ( Errington et al., 2014 ). This Registered Report describes the proposed replication plan of key experiments from “Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET” by Peinado and colleagues, published in Nature Medicine in 2012 ( Peinado et al., 2012 ). The key experiments being replicated are from Figures 4E, as well as Supplementary Figures 1C and 5A. In these experiments, Peinado and colleagues show tumor exosomes enhance metastasis to bones and lungs, which is diminished by reducing  Met  expression in exosomes ( Peinado et al., 2012 ). The Reproducibility Project: Cancer Biology is a collaboration between the  Center for Open Science  and  Science Exchange  and the results of the replications will be published in  eLife .

Registered report: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET