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The final identity of a differentiated neuron is determined by multiple signaling events, including activity dependent calcium transients. Non-canonical Frizzled2 (Fz2) signaling generates calcium transients that determine neuronal polarity, neuronal migration, and synapse assembly in the developing vertebrate brain. Here, we demonstrate a requirement for Fz2/Ca 2+  signaling in determining the final differentiated state of a set of central brain dopaminergic neurons in  Drosophila , referred to as the protocerebral anterior medial (PAM) cluster. Knockdown or inhibition of Fz2/Ca 2+  signaling during maturation of the flight circuit in pupae reduces  Tyrosine Hydroxylase  ( TH ) expression in the PAM neurons and affects maintenance of flight. Thus, we demonstrate that Fz2/Ca 2+  transients during development serve as a pre-requisite for normal adult behavior. Our results support a neural mechanism where PAM neuron send projections to the α' and β' lobes of a higher brain centre, the mushroom body, and function in dopaminergic re-inforcement of flight.

Maturation of a central brain flight circuit in Drosophila requires Fz2/Ca 2+ signaling