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Interactions between all three pigment cell types are required to form the stripe pattern of adult zebrafish ( Danio rerio ), but their molecular nature is poorly understood. Mutations in  leopard  ( leo ), encoding Connexin 41.8 (Cx41.8), a gap junction subunit, cause a phenotypic series of spotted patterns. A new dominant allele,  leo   tK3  , leads to a complete loss of the pattern, suggesting a dominant negative impact on another component of gap junctions. In a genetic screen, we identified this component as Cx39.4 ( luchs ). Loss-of-function alleles demonstrate that  luchs  is required for stripe formation in zebrafish; however, the fins are almost not affected. Double mutants and chimeras, which show that  leo  and  luchs  are only required in xanthophores and melanophores, but not in iridophores, suggest that both connexins form heteromeric gap junctions. The phenotypes indicate that these promote homotypic interactions between melanophores and xanthophores, respectively, and those cells instruct the patterning of the iridophores.

Gap junctions composed of connexins 41.8 and 39.4 are essential for colour pattern formation in zebrafish