English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

All motor behaviors require precise temporal coordination of different muscle groups. Breathing, for example, involves the sequential activation of numerous muscles hypothesized to be driven by a primary respiratory oscillator, the preBötzinger Complex, and at least one other as-yet unidentified rhythmogenic population. We tested the roles of  Atoh1- ,  Phox2b- , and  Dbx1- derived neurons (three groups that have known roles in respiration) in the generation and coordination of respiratory output. We found that  Dbx1 -derived neurons are necessary for all respiratory behaviors, whereas independent but coupled respiratory rhythms persist from at least three different motor pools after eliminating or silencing  Phox2b-  or  Atoh1 -expressing hindbrain neurons. Without  Atoh1  neurons, however, the motor pools become temporally disorganized and coupling between independent respiratory oscillators decreases. We propose  Atoh1  neurons tune the sequential activation of independent oscillators essential for the fine control of different muscles during breathing.

Atoh1 -dependent rhombic lip neurons are required for temporal delay between independent respiratory oscillators in embryonic mice