Estimating parameters of the Hodgkin-Huxley cardiac cell model by integrating raw data from multiple types of voltage-clamp experiments

The ion channel currents are expressed as follows, where m, h, and j are gating variables that regulate the activation, an slow and fast inactivation of the sodium channel, respectively. The two addends represent the sodium and potassium channel currents, denoted INa and IK, respectively. Excluding parameters associated with the IK, the model has 14 free parameters. Iion = gNam hj(V − ENa) + gK(V − EK)e −(V−EK)/kr