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Recent advances in molecular genetics have provided hundreds of thousands of singlenucleotide polymorphisms (SNPs) to detect mutations in genes related with complex traits.Undetected shared ancestry within samples of individuals could lead to the detection offalse genomic signals in association mapping. Pedigree-based relationship matrices orgenomic relationship matrices could be used in a mixed model to predict and correct forgenetic stratifications. Genotypic information of founder populations could also be used toexplore patterns of inheritance for complex traits by admixture mapping. An F<sub>2</sub> populationwas created using M16 and ICR mouse lines for studying body weight at 8 weeks of age.Genotypes were collected for 1813 SNPs for each animal, including the founders. Bayesianresiduals were used for population stratification in the admixture model. Association andadmixture mapping detected similar genomic signals from chromosome 10. Our resultsprovide empirical proof that gene flow from ancestral populations could be traced byadmixture mapping with founder genotypes

Empirical comparison of association and admixture mapping for body weight using F&lt;sub&gt;2&lt;/sub&gt; mice data set

Empirical comparison of association and admixture mapping for body weight using F<sub>2</sub> mice data set