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Kratom leaves (Mitragyna speciosa Korth.) is known to have an opioid-like analgesic effect. One of the main compound in kratom leaf is mitragynine which has strong affinity to opioid receptor. Kratom leaf has many pharmacological effects, one of them is as an antinociceptive agent. The purpose of this research was to investigate the antinociceptive effect of dicholoromethane fraction from kratom leaf and determine the percentage of antinociceptive activity on male Swiss mice. The method used in this study was hot plate method. The animal subjects were divided into five groups: normal group was induced with CMC Na 0.5%, control group with morphine 5.46 mg/ kgBW, and group with dicholoromethane fraction of kratom leaf doses 70 (51%), 140 (81%), and 280 mg/kgBW (86%) respectively. The subject response like jump, lick or lift up the back leg was considered as latent time parameter. The latent time was recorded at 0, 15, 30, 45, 60, 90, 105 and 120 minutes with cut-off time 15 seconds. Result data were analysed using One Way ANOVA and Post Hoc Test LSD. It showed the antinociceptive effect of dichloromethane fraction at dose 70, 140 and 280 mg/kgBW were significantly difference (p<0.05) with normal group. The conclusion of this study is the dichloromethane fraction of kratom leaf has antinociceptive activity. The percentage of antinociceptive from fraction group at dose 280 mg/kgBW was higher than the other two dose-groups (140 and 70 mg/kgBW).

Aktivitas Antinosiseptif Fraksi Diklorometana Daun Kratom (Mitragyna speciosa Korth.) Rute Oral Pada Mencit Jantan Swiss