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Many applications and industrial processes require very low cooling temperature, such as cold storage in the biomedical field, requiring temperature below -80 °C. However,single-cycle refrigeration systems can only achieve the effective cooling temperature of -40 °C and, also, the performance of the cycle will decrease drastically for cooling temperatures lower than -35°C. Currently, most of cascade refrigeration systems use refrigerants that have ozone depletion potential (ODP) and global warming potential (GWP), therefore, in this study, a cascade system is simulated using a mixture of environmentally friendly refrigerants, namely, carbon dioxide and a hydrocarbon (propane, ethane or ethylene) as the refrigerant of the low temperature circuit. A thermodynamic analysis is performed to determine the optimal composition of  the  mixture  of  carbon  dioxide  and  hydrocarbons  in  the  scope  of  certain  operating  parameters.  In  addition,  an economic analysis was also performed to determine the annual cost to be incurred from the cascade refrigeration system. The  multi-objective/thermoeconomic  optimization  points  out  optimal  operating  parameter  values  of  the  system,  to \udaddressing both exergy efficiency and its relation to the costs to be incurred

Thermoeconomic Optimization of Cascade Refrigeration System Using Mixed Carbon Dioxide and Hydrocarbons at Low Temperature Circuit