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The incidence of infections in preterm infants is still quite high. In this study, oral care with human breast milk was implemented in risk preterm infants as a precaution. The study was conducted using a quasi-experimental method with a non- equivalent control group and posttest only design in 40 risk preterm infants. The participants were divided into two groups of 20. The data were analyzed using independent t-test and a Wilcoxon test. The results show that this intervention has an effect on the incidence of late-onset sepsis in preterm infants. The effect is based on symptoms: body temperature instability ( p = 0.021), C-reactive protein ( p = 0.006), and leukocytes ( p = 0.020) all indicated differences between the two groups. It is recommended that this practice be adopted as a routine therapy program in perinatology. Keywords: exclusive breastfeeding, late-onset sepsis, oral care, risk preterm infants, sepsis Abstrak Perawata n Mulut Mencegah Sepsis Neonatorum Awitan Lambat pada Bayi Prematur Risiko Tinggi. Angka kejadian infeksi setelah lahir pada bayi prematur masih cukup tinggi. Pelaksanaan intervensi pemberian oral care menggunakan air susu ibu pada bayi prematur risiko tinggi telah dilakukan sebagai pencegahan. Penelitian dilakukan menggunakan metode kuasi eksperimen dengan desain post-test only, kelompok kontrol non ekuivalen, pada 40 bayi prematur risiko tinggi sebagai sampel. Responden dibagi menjadi dua kelompok, masing-masing kelompok 20 responden. Data dianalisis menggunakan uji t independen dan wilcoxon. Hasil Intervensi ini terbukti memiliki manfaat terhadap dalam menurunkan kejadian sepsis neonatorum awitan lambat pada bayi prematur berdasarkan tanda klinis seperti ketidakstabilan suhu tubuh (p value 0,021), hasil pemeriksaan C-Reaktif Protein (p value 0,006) dan leukosit (p value 0,020) yang menunjukkan adanya perbedaan yang bermakna antara kelompok kontrol dan kelompok intervensi. Intervensi ini diharapkan dapat dilanjutkan menjadi program terapi rutin yang akan dilakukan di ruang rawat perinatologi. Kata Kunci: ASI eksklusif, bayi prematur, oral care, sepsis, sepsis neonatorum awitan lambat

Oral Care Prevents Late-Onset Sepsis in Risk Preterm Infants