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Abstrak Ekspresi transforming growth factor beta 1 pada luka diabetes melitus mengalami penurunan yang berdampak terhadap proses penyembuhan luka. Penelitian ini bertujuan untuk membandingkan perawatan luka modern dressing dengan metode konvensional terhadap ekspresi transforming growth factor beta 1 pada luka kaki diabetes melitus. Penelitian menggunakan quasi experimental pretest-posttest design dengan metode pengumpulan sampel secara consecutive sampling. Pengukuran ekspresi transforming growth factor beta 1 dilakukan pada hari ke-0 ( pretest ) dan ke-4 ( posttest ). Hasil penelitian didapatkan data pada kelompok modern terjadi peningkatan ekspresi transforming growth factor beta 1 , sedangkan pada kelompok konvensional terjadi penurunan ekspresi transforming growth factor beta 1 . Disimpulkan bahwa teknik perawatan luka secara modern mampu meningkatkan ekspresi transforming growth factor beta 1 dibandingkan teknik konvensional pada luka kaki diabetes melitus. Abstract Reduction of expression of transforming growth factor beta 1 in diabetic ulcers affects overall wound healing. This study tried to draw a comparison of transforming growth factor beta 1 level between modern dressing and conventional dressing in diabetic foot ulcer. This study applied a quasi-experimental pretest-posttest design and a consecutive sampling method of data collection. Immunohistochemical analysis of transforming growth factor beta 1 level was measured on the day 0 (pretest) and the day 4 (posttest). In this study, the modern dressing application improves transforming growth factor beta 1 level. Meanwhile, the conventional dressing application decreases transforming growth factor beta 1 level. Thus, it can be concluded that the modern dressing application can increase transforming growth factor beta 1 level.

Peningkatan Ekspresi Transforming Growth Factor Beta 1 (TGF β1) Pada Luka Diabetes Melitus Melalui Balutan Modern