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Background: The aim of the study was to estimate the cost-effectiveness of addition of human papillomavirus (HPV) vaccination to the Polish cervical cancer prevention programme. Methods: A cost-utility analysis was conducted. A lifetime Markov model, adapted to Polish settings, was used to compare the costs and health outcomes of the two strategies, i.e. the existing cervical cancer prevention programme with or without universal HPV vaccination in girls at the age of 14. Results: Assuming that the whole cohort was vaccinated (100% vaccination coverage), the estimated lifetime risk of developing cervical cancer would be reduced from 0.95% to 0.23%; therefore, 1311 cases of cervical cancer and 681 deaths due to cervical cancer would be prevented in a cohort of 182,000 girls aged 14 years.If the assumed vaccination coverage was 24%, the cost of gaining an additional quality-adjusted life year (QALY) due to HPV vaccination as an extension of the cervical cancer prevention programme would be PLN 52,737.91/QALY and PLN 76,288.47/ QALY from the public payer’s perspective and the common perspective of the public payer and the patient, respectively.This cost effectiveness is maintained for different parameter

journal of health policy and outcomes research

Cost-effectiveness analysis of Human Papillomavirus (HPV) vaccination using Cervarix® as an extension to the cervical cancer prevention programme in Poland