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The antimicrobial activity of Caesalpinia bonducella extracts such as CLC, CLE, CSC, and CSE and the phytoconstituents such as β-Sitosterol (LC3) isolated from CLC and methyl (4E)-5-{2-[(1E)-buta-1,3-dien-1-yl]4,6-dihydroxyphenyl} pent-4-enoate (SC2) isolated from CSC were evaluated on gram-positive and gram-negative bacteria. The extracts and isolated compounds were found to have moderate-to-significant bacterial inhibition. The significant activity was observed in the inhibition of Pseudomonas aeruginosa by CLC extract (16.10 ± 1.10 mm), whereas the isolated phytocomponent SC2 showed the highest inhibition (16.50 ± 0.58 mm). Further, the isolated compounds were subjected to molecular docking studies of the bacterial DNA Gyrase. The in silico study showed the docking energy of −6.4 and three hydrogen bonding. This in vitro and in silico analysis of extracts and isolated phytocomponents of C. bonducella helps to understand and evaluate the therapeutic efficacy to cure infectious diseases and also supports the traditional medicinal claim as an antibiotic. ARTICLE INFO Article history: Received on: July 30, 2018 Available online: April 05, 2019

Antibacterial potential of Caesalpinia bonducella extracts and their isolated phytoconstituents: in vitro and in silico analysis