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Cancer has been considered one of these major community healthiness problems. Althaea ludwigii L. (family: Malvaceae) is an indigenous plant, widely distributed in Iraq. The objective of this study is to explore the antiproliferative action of A. ludwigii L. against breast cancer cell line Michigan Cancer Foundation-7 (MCF-7) and rate embryonic fibroblasts (REF) normal cell line and to identify the bioactive constituent. The aerial parts of A. ludwigii L. were grinded into fine powder then extracted with 85% methanol. Methanol extract was further partitioned with ethyl acetate. Ethyl acetate fraction was chosen to test against MCF-7 by (3-[4, 5-dimethylthiazol-2-yl]-2, 5 (MTT assay) the bioactive constituents were investigated by high performance thin layer chromatography high-performance thin-layer chromatography (HPTLC). The data showed that ethyl acetate fraction has significant antiproliferative activity against MCF-7 (IC50 = 35.5 μg/ml) and REF (IC50 = 1762.9 μg/ml), HPTLC showed the existence of rutin in ethyl acetate fraction. The antiproliferative activity may relate to the existence of rutin which had been approved as potent anticancer. ARTICLE INFO Article history: Received on: September 21, 2018 Accepted on: December 01, 2018 Available online: April 05, 2019

Antiproliferative activities of Althaea ludwigii L. extract on Michigan Cancer Foundation-7 breast cancer cell line