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This study aims to evaluate the potential of endophytic fungi isolated from Gandaria (Bouea macrophylla Griffith) as sources of enzyme inhibitor, antibacterial, and antioxidant and identify the chemical compounds of active extract. The endophytic fungi were identified as fungi closely related to the genus Neofusicoccum ribis based on sequence analysis of the 28S rDNA and internal transcribed spacer region. N. ribis was cultured on potato dextrose broth and extracted with hexane, ethyl acetate, and partition between methanol and ethyl acetate, respectively. Bioactivity screenings as enzyme inhibitor (acetylcholinesterase/acetylcholinesterase inhibitor (AChE) and β-glucosidase), antibacterial, and antioxidant were conducted by thin-layer chromatography-bioautography method. The chemical compounds were analyzed by gas chromatography-mass spectrometry (GC-MS). The results showed that the ethyl acetate extract of N. ribis had the activity as enzyme inhibitor for AChE and β-glucosidase. The minimum inhibitory concentration values of N. ribis extract against Staphylococcus aureus and Escherichia coli were in the range of 512–>512 μg/mL. Hexane extract had better antioxidant activity (IC50 = 479.66 μg/mL) than ethyl acetate extract (IC50 = 928.09–1102.60 μ g/mL). The GC-MS analysis showed that 12 identified chemical compounds were found in the ethyl acetate extract of N. ribis.

A study of endophytic fungi Neofusicoccum ribis from Gandaria (Bouea macrophylla Griffith) as enzyme inhibitor, antibacterial, and antioxidant