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The present study was designed to evaluate the effects of Senna occidentalis in alloxan-induced diabetic and its complications in Wistar rats. Thirty male Wistar rats with body weight ranging from 180–250 g were selected for the study. Diabetes was induced by single intraperitoneal dose of alloxan injection (150 mg/ kg body weight). Treatment was carried out orally using aqueous and ethanol extracts of Senna occidentalis leaves at 100 mg/kg body weight once daily for 21-days. The fasting blood sugar (FBS), Thiobarbituric acid Reactive Substance (TBARS), alkaline Phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum bilirubin and full blood count levels were evaluated. The result of the study showed decrease in FBS, TBARS, liver enzymes, bilirubin, platelets (PLT) and white blood count (WBC) as well as increase in lymphocytes (LYM) and red blood count (RBC). The result of study showed to a large extent the effects of Senna occidentalis in the management of some complications resulting from diabetes and its complications.

Modulation of some biochemical complications arising from alloxan-induced diabetic conditions in rats treated with Senna occidentalis leaf extract