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In this study, Polygomun aviculare L. (P. aviculare L.) extract loaded elastic liposomes (ELPs) were inves- tigated to enhance the transdermal delivery of P. aviculare L. extract composed of various flavonoids. ELPs were com- posed of egg phospholipids (PC) and edge activator (Tego ® care 450) and the physical properties and in vitro permeation studies of ELPs were performed. Particle size ranged from 148.1 to 262.2 nm and deformability index was recorded as 11.5~25.4. Loading efficiency was from 53.1 to 66.3%. In vitro skin permeation studies using Franz diffusion cell dem- onstrated that ELP-4 having ratio of 85:15 for PC to Tego ® care 450 exhibited the higher skin permeability than ELP- 1, the general liposome without Tego ® care 450. It was visually seen by fluorescence image restoration microscopy. The findings suggest that ELP-4 selected as the optimal formulation could be used as useful formulation for transdermal deliv- ery of the extract.

Physical Characterizations and In Vitro Skin Permeation of Elastic Liposomes for Transdermal Delivery of Polygonum aviculare L. Extract