Open AccessAntitumor Activity of Lentivirus-mediated Interleukin -12 Gene Modified Dendritic Cells in Human Lung Cancer in Vitro
Author(s) -
HASSAN ABDELLAH AHMED ALI,
Jun Di,
Mei Wu,
Yucheng Zhang,
Yi Li,
Zhenwu Du,
Guizhen Zhang
Publication year - 2014
Publication title -
asian pacific journal of cancer prevention
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 75
eISSN - 2476-762X
pISSN - 1513-7368
DOI - 10.7314/apjcp.2014.15.2.611
Subject(s) - cytotoxic t cell , antigen , tumor antigen , cancer research , dendritic cell , interleukin 15 , interleukin 12 , microbiology and biotechnology , biology , immunotherapy , ctl* , immunology , immune system , interleukin , cytokine , in vitro , cd8 , biochemistry
Dendritic cell (DC)-based tumor immunotherapy needs an immunogenic tumor associated antigen (TAA) and an effective approach for its presentation to lymphocytes. In this study we explored whether transduction of DCs with lentiviruses (LVs) expressing the human interleukin-12 gene could stimulate antigen- specific cytotoxic T cells (CTLs) against human lung cancer cells in vitro.
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