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We read with interest Ge et al. (2012) article entitled “Occupational Cooking and Risk of Uveal Melanoma: a Metaanalysis”. We believe that this meta-analysis is helpful because a synthesis of the growing evidence of the association between cooking and uveal melanoma risk is overdue. Uveal melanoma is a rare disease and only a few consistent risk factors have been identified (Behrens et al., 2011; Epidemiologisches Krebsregister NRW, 2013). However, we are concerned about three aspects. First, the authors included published study results that were not derived from independent study samples. Guenel et al. (2001), Stang et al. (2003), Lutz et al. (2005) and Behrens et al. (2011) used data of the multicentric case– control study entitled “Study of Occupational Risk Factors for Rare Cancers of Unknown Aetiology” (in short “Rare Cancer Study”) from nine European countries (Ge et al., 2012). Guenel et al. (2001). similar to Stang et al. only included their national data, that is, French and German data, respectively. Lutz et al. used data from Italy, Denmark, Latvia, Sweden, Spain, Portugal. That means, these three papers used disjunct data sets from the international Rare Cancer Study. Finally, Behrens et al. (2011) used the largest data set of the Rare Cancer Study including France, Germany, Italy, Denmark, Latvia, Sweden, Spain, Portugal, UK. Therefore, the effect estimate from Behrens et al. is not independent of the effect estimates presented in the previous papers of the Rare Cancer Study (Table 1). We therefore excluded the data from Behrens et al. and re-ran the metaanalysis of Ge et al. (2012) to avoid statistical dependence between the study-specific effect estimates. We provide both results from the fixed-effect and from the random-effect model. The newly estimated Comparison of Apples with their Parts: Rethinking a Metaanalysis on the Association between Cooking and Uveal Melanoma Risk

Comparison of Apples with their Parts: Rethinking a Meta-analysis on the Association between Cooking and Uveal Melanoma Risk