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The aim of the study was to determine the individual and combined toxic effects of the herbicide Fozat 480 (glyphosate [isopropylamine salt] 480g/l) and cadmium sulphate (CdSO4) on the development of chicken embryos. On the first day of incubation, chicken eggs were injected with 0.1 ml of cadmium sulphate solution (0.1%) and/or with 0.1 ml of Fozat 480 (2.0%). The chicken embryos were examined on the 19th day by measuring the rate of embryo mortality and body weight and by identification of different types of developmental anomalies and macroscopic malformations. The body weight data were statistically evaluated by one-way ANOVA and Dunnett tests, while the embryonic mortality and the developmental anomalies were analysed by Fisher test. Our teratogenicity study revealed, that the combined administration of cadmium sulphate and glyphosate (isopropylamine salt) containing herbicide formulation caused a significant reduction in the body weight of embryos and increased the rate of embryonic mortality. The joint toxic effect of cadmium sulphate and Fozat 480 is an additive effect compared to the individual toxicity of the test materials.

STUDIES ON JOINT TOXIC EFFECTS OF A GLYPHOSATE HERBICIDE (FOZÁT 480) AND A HEAVY METAL (CADMIUM) ON CHICKEN EMBRYOS