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Drug reaction in hospitalized patients has an incidence rate of 2–3% and can affect any organ of the body, including the skin and its appendages. Each of the components of the nail apparatus can be affected, and the clinical manifestation to be observed will depend on the condition of each component. When it comes to the periungual folds, fixed drug eruptions, Stevens–Johnson syndrome, and Lyell’s syndrome are the associated skin drug reactions. Periungual lesions can manifest themselves as a condition per se or arise from a drug reaction. Erythema, hemorrhage, necrosis, painful desquamation, edema, vesicles, and dyschromia are among the lesions that can develop. Other possible reactions include paronychia and the formation of pyogenic granulomas caused by drugs. Therefore, it is important to assess the periungual folds should any drug reaction occur.

Drug reactions with the involvement of the periungual folds