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The exact cause of vitiligo is unknown [1,4]. It is believed to be due to genetic susceptibility that is surely evoked by an environmental factor such an autoimmune disease [1,2,5]. All this yields to the destruction of skin pigment cells. Risk factors include a family history of the condition or other autoimmune diseases, such as hyperthyroidism, alopecia areata, and pernicious anemia [2]. It is not contagious. There is no known cure for vitiligo. For those with light skin, sunscreen and makeup are all that is typically recommended. Another treatment is phototherapy to darken the light patches [1,6]. Alternatively, efforts to lighten the unaffected skin, such as with hydroquinone or methylhydroquinone, may be tried especially in black people [2]. Globally about 1% of people are affected by vitiligo. In India and circumstant lands people affected by vitiligo show rates as high as 2–3% [7,8]. Vitiligo has been described since ancient history [1,9].

Novelties in the field of treatment of Vitiligo: DHA, caramel and Rattany that acts even as UV screen