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Lesions identical to those of acrokeratosis verruciformis are also observed in many patients with acral Darier disease (also termed keratosis follicularis) or even in relatives of individuals with Darier disease. Considerable controversy surrounds the nature and relationship of acrokeratosis and Darier disease and whether they are manifestations of one genetic abnormality. Some authors suggest that acrokeratosis verruciformis of Hopf and Darier disease are distinct entities, while others maintain that they are variable expressions of the same disease, with the former being a mild expression or a forme fruste of the latter. Recent genetic studies review show these may be distinct entities that are allelic variants [2].

Usage of unsaturated esters of retinol to defeat Hopf’s acrokeratosis verruciformis in hands and feet of a youg man