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Objectives :To provide information on the safety of ACM, we carried out a 13-week repeated oral dose toxicity and a 4-week recovery test of ACM in Sprague-Dawley rats.Methods :Female and male rats were treated with ACM with oral doses of 800, 2000, and 5000 ㎎/㎏. The ACM was administered for 13 weeks. Mortality, clinical signs, body weig ht changes, food consumption, ophthalmologic findings, urinalysis, hematological and biochemical parameters, gross findings, organ weights and histological markers were monitored during the study period. Moreover, the rats were monitored for 4 extra weeks to determine recovery time after the study period.Results :We found no mortality and no abnormalities in clinical signs, b ody weight, food consumption, ophthalmologic findings, urinalysis, hematological and biochemical parameters, gross findings, organ weights and histological markers in any of the rats tested.Conclusions :The no-observed adverse effects level (NOAEL) was considered as over 5000 mg/kg for male and female rats.Key Words :ACM, Added Chongmyung-Tang, 13 week repeated oral dose toxicity test, 4 week recovery test, SD rats. Received : August 17, 2012; Revised : September 13, 2012; Accep ted : September 13, 2012Correspondence : In-Chul Jung, Address : Daejon Univ. College o f Oriental Medicine, Yongun-dong, Dong-gu, Daejeon, Korea.Tel : +82-42-470-9129, Fax : +82-42-470-9006, E-mail : npjeong @dju.ac.kr* This study was supported by agrant of the Traditional Korean Medicine R&D Project, Ministry of Health & Welfare, Republic of Korea. (Task-specific number: B090020).

A Thirteen Week Repeated Oral Dose Toxicity Test and A Four Week Recovery Test of ACM(Added Chongmyung-tang) in Sprague-Dawley Rats