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Objectives : This research investigates the effect of the JCT extract regarding Alzheimer's disease. Methods : The effects of the JCT extract on IL-1β, IL-6, TNF-α, COX-2, NOS-II mRNA, APP mRNA, BACE mRNA, Nitric oxide(NO), and βA protein production in the BV2 microglia cell lines treated with LPS and βA were investigated. Results : 1. The JCT extract suppressed the expression of IL-1β, IL-6, TNF-α, COX-2, and NOS-II mRNA in BV2 microglial cell line treated with LPS and βA. 2. The JCT extract suppressed the expression of BACE and APP mRNA in BV2 microglial cell line treated with LPS and βA. 3. The JCT extract suppressed the expression of Nitric oxide(NO) in BV2 microglial cell line treated with LPS and βA. 4. The JCT extract suppressed the expression of βA protein prod uction in BV2 microglial cell line treated with LPS and βA. Conclusions : These results suggest that the JCT group may be effective for t he treatment of Alzheimer's disease. Thus, JCT could be considered among the future therapeutic drugs indicated for the treatment of Alzheimer's disease.

The Effects of Jeoreongchajeonja-tang(Zhulingjuqianzi-tang) on the βA and LPS Induced BV2 microglial cell