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Objective: Oxidative/nitrosative stress may be triggered by a various sources and ionizing radiation may also initiate oxidative/nitrosative stress. This is the first study, we aimed to investigate the induction of oxidative and nitrosative stress due to ionizing radiation in patients undergoing Tc-99m pertechnetate thyroid scintigraphy. Method: Totally 26 patients (16 female,10 male) undergoing Tc-99m pertechnetate thyroid scintigraphy were included in this study. The patients were aged between 20 and  50 years (58.0±16.3 years). The blood samples were taken from patients  20  minutes  after intravenous injection of  Tc-99m pertechnetate  in dose used clinically (5 miliCurie) before the patients were taken to the thyroid imaging. Control group was selected from 30 healthy subjects (15 female,15 male). The control group was aged between 17 and 72 years (57.0±14.0 years). The blood samples were taken both patients and control group for measuring antioxidant enzymes (catalase and superoxide dismutase), malondialdehyde, nitric oxide and nitrotyrosine as oxidative/nitrosative stress biomarkers. Results: In this study we found that activities of antioxidant enzymes inreased in patients compared to control (p<0.05). Further, malondialdehyde levels as an indicator of oxidative stress were higher in patients than control group (p<0.05).The levels of nitric oxide and nitrotyrosine as nitrosative stress biomarkers also increased in patients compared to control groups (p<0.05).    Conclusions: We thought that Tc-99m pertechnetate may cause an increase in reactive oxygen and nitrogen species and may cause oxidative/nitrosative damage at the cellular level. Our results indicated that the dose of Tc-99m pertechnetate given in these patients undergoing thyroid scintigraphy can tolerable.

Induction of oxidative/nitrosative stress following Tc-99m pertechnetate thyroid scintigraphy in human