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SUMMARY Hiccups can be defined as the sudden, uncontrolled contractions of the diaphragm, followed by immediate inspiration and closure of the glottis over the trachea. Various etiologies are responsible for this reflex action such as instrumentations, gastrointestinal, cardiovascular, toxic-metabolic factors, and drugs. Most common drugs that may trigger hiccups are opioids, barbiturates, some antibiotics, chemotherapeutic agents, and steroids. Since steroids are one of the most common drugs in neurology practice, we here presented a patient with relapsing-remitting multiple sclerosis that experienced persistent hiccups after intravenous methyl- prednisolone treatment, to emphasize the side-effect of the drug. Keywords: Hiccups, intravenous methyl-prednisolone, side effect OZET Hickirik, trakenin uzerinden glottisin kapanmasi ve ani inspirasyon ile takip edilen, diyaframin ani ve kontrol edilemeyen kasilmalari olarak tanimlanabilir. Bu refleks eylemden enstrumentasyon, gastrointestinal, kardiyovaskuler, toksik-metabolik faktorler ve ilaclar gibi cesitli etiyolojiler sorumludur. Hickirigi siklikla tetikleyen ilaclar opiatlar, barbituratlar, bazi antibiyotikler, kemoterapotik ajanlar ve steroidlerdir. Steroidler noroloji pratiginde en sik kullanilan ilaclardan biri oldugundan, intravenoz metilprednizolon sonrasi inatci hickirik ortaya cikan, atak ve iyilesmelerle giden bir multiple skleroz hastasini, ilacin yan etkisini vurgulamak amaciyla sunduk. Anahtar sozcukler: Hickirik, intravenoz metilprednizolon, yan etki

cumhuriyet tıp dergisi/cumhuriyet üniversitesi tıp fakültesi dergisi

Persistant hiccups due to the use of intravenous metilprednisolone in a patient wit relapsing remitting multiple sclerosis: a case report and literature review