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SUMMARY Objective : To investigate the relationship between autoimmune thyroid disease and vitamin D treatment. Method : Fifty four (54) patients with both vitamin D deficiency and newly diagnosed euthyroid Hashimoto’s thyroiditis (HT) were recruited for this study. The patients were given intramuscular administration of cholecalciferol at a dose of 300,000 IU/month for 3 months. At the time of diagnoses and after the treatment of vitamin D, free T3 (FT3), free T4 (FT4), thyroid stimulating hormone (TSH), antithyroid peroxidase (anti-TPO), antithyroglobulin (anti-TG), 25 (OH) D3, parathormone (PTH), calcium (Ca), phosphorus (P) and alkaline phosphatase (ALP) levels were measured in all patients; TNF-a, IL-6 and IL-1s levels were measured in only 43 patients. Results: A statistically significant difference (p˂0.05) was observed between the pre and post treatment FT4, TSH, antiTPO, antiTG, PTH and ALP levels. After the treatment of vitamin D, a statistically significant increase was found in 25 (OH) D3 and FT4 levels, and a significant decrease was found in TSH, antiTPO, antiTG, PTH and ALP levels, whereas no significant difference was noted in FT3, Ca, P, TNF- a, IL-6 and IL-1s levels. Further, levels of vitamin D were not correlated with FT3, FT4, TSH, antiTPO, antiTG, TNF-a, IL-6 and IL-1s levels (p˃0.05). Conclusions: For patients with both vitamin D deficiency and newly diagnosed HT, treatment of vitamin D had a positive effect on the thyroid antigenicity and thyroid function. Keywords: Autoimmune thyroid disease, Hashimoto's thyroiditis, Vitamin D deficiency OZET Amac: D vitamini tedavisinin otoimmun tiroid hastaligi ile iliskisini arastirdik. Yontem: Calismaya D vitamini yetersizligi ve beraberinde yeni tani alan Hashimoto tiroiditi olan (HT) 54 hasta alindi. Hastalara 3 ay sureyle ayda bir 300.000 IU kolekalsiferol intramuskuler olarak verildi. Tani esnasinda ve D vitamini tedavisi sonrasinda serbest T3(FT3), serbest T4 (FT4), tiroid stimulan hormon (TSH), anti tiroid peroksidaz (TPO) ve anti tiroglobulin (TG), 25(OH)D3, parathormon (PTH), kalsiyum (Ca), fosfor (P) ve alkalen fosfataz (ALP) seviyeleri ve yalniz 43 hastada TNF- α, IL-6, IL-1b seviyeleri olculdu. Bulgular: Tedavi oncesi ve sonrasi FT4, TSH, antiTPO, antiTG, PTH ve ALP seviyeleri acisindan arada istatistiksel olarak anlamli fark vardi (p<0.05). D vitamini tedavi sonrasinda 25 (OH) D3 ve FT4 seviyelerinde istatiksel olarak onemli bir artis olurken TSH, antiTPO, antiTG, PTH ve ALP seviyelerinde ise onemli bir dusus gozlendi. FT3, Ca, P, TNF- α, IL-6 ve IL-1b acisindan onemli bir fark yoktu. D vitamini seviyesi ile FT3, FT4, TSH, antiTPO, antiTG,  TNF- α, IL-6 ve IL-1b arasinda bir korelasyon yoktu. Sonuc: D vitamini eksikligi ve yeni tani HT’i olan hastalarda D vitamini tedavisinin tiroid antijenitesi ve tiroid fonksiyonu uzerine olumlu yonde etkisi vardir. Anahtar sozcukler: Otoimmun tiroid hastaligi, Hashimoto tiroiditi, D vitamini yetersizligi

cumhuriyet tıp dergisi/cumhuriyet üniversitesi tıp fakültesi dergisi

The effect of Vitamin D treatment on thyroid function and the levels of thyroid autoantibodies, TNF-α, IL-6, IL-1β in patients with autoimmune thyroiditis