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BACKGROUND: The aim of the study was to determine the frequency of the use of proton pump inhibitors (PPI) and histamine-2 receptor antagonists (H2RA), which are widely used drugs, in the medical wards. MATERIALS AND METHODS: We retrospectively retrieved medical records of the patients who were hospitalized between January 1st and December 31th, 2010 in a tertiary care university hospital internal medicine wards and medical intensive care unit (MICU); one fourth of the cases who used a H2RA or a PPI drugs were randomly selected for the study. RESULTS: In 2010, half of 4730 patients who admitted to internal medicine wards was ordered a H2RA or a PPI. Of these, 556 patients (25.5%) were evaluated. Majority of the patient (76%) were on PPI. While 90.3% of the patients used a PPI in wards, 74.8% of the patients used a H2RA in the MICU (p<0.001). Sixty-one percent (58/95) of patients who were transferred from the MICU to wards were switched from a H2RA to a PPI without a specific reason.  Before admission, 8% of patients was on PPI and 5% on H2RA but at discharge, utilization significantly increased, 79% for PPI and 21% for H2RA (p<0.001). CONCLUSION: There is a high rate of acid suppressive therapy usage among hospitalized patients and similarly high rate of prescription at discharge. Further studies are required to evaluate the appropriateness of the utilization of these drugs.

Overutilization of proton pump inhibitors and H2 receptor antagonists in hospitalized medical patients