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Disseminated tuberculosis (TB) is a life-threatening condition which is often a challenge to diagnose. When to use bone marrow biopsies to diagnose disseminated TB in paediatrics is always a dilemma, from both a clinical and laboratory perspective, as there are no clear guidelines. Our study primarily aims to evaluate the role of routine bone marrow biopsies, and to compare peripheral blood cultures to aspirate cultures in the diagnosis of disseminated TB, in a paediatric population at Tygerberg Hospital. In addition, we set out to assess the morphology of bone marrow biopsies in this study.

Bone marrow morphological features and diagnostic value in paediatric disseminated tuberculosis in the setting of increased HIV prevalence