Open AccessEmergence of plasmid-mediated colistin resistance (MCR-1) among Escherichia coli isolated from South African patients
Author(s) -
Jennifer Coetzee,
Craig Corcoran,
Elizabeth Prentice,
Vineshree Mischka Moodley,
Marc Mendelson,
Laurent Poirel,
Patrice Nordmann,
Adrian Brink
Publication year - 2016
Publication title -
south african medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 57
eISSN - 2078-5135
pISSN - 0256-9574
DOI - 10.7196/samj.2016.v106i5.10710
Subject(s) - colistin , mcr 1 , polymyxin , medicine , klebsiella pneumoniae , antibiotics , microbiology and biotechnology , enterobacteriaceae , drug resistance , escherichia coli , bacteria , antibiotic resistance , biology , gene , genetics , biochemistry
The polymyxin antibiotic colistin is an antibiotic of last resort for the treatment of extensively drug-resistant Gram-negative bacteria, including carbapenemase-producing Enterobacteriaceae. The State of the World's Antibiotics report in 2015 highlighted South Africa (SA)'s increasing incidence of these 'superbugs' (3.2% of Klebsiella pneumoniae reported from SA were carbapenemase producers), and in doing so, underscored SA's increasing reliance on colistin as a last line of defence. Colistin resistance effectively renders such increasingly common infections untreatable.
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