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Extracted from text ... Leucocyte depletion of blood components - guidelines ofthe Blood Transfusion Services of South AfricaArthur Bird, Robert CrookesLeucocytes in blood components are responsible for a numberof adverse effects associated with blood transfusion. In manyinstances the pathogenesis has not been elucidated precisely,but it is likely that it is immunologically mediated. Potentialmechanisms include clonal deletion or anergy, inductionof suppressor cells, production of anti-idiotypic antibody,suppression of natural killer (NK) cell activity and severalothers.1 As a consequence a number of clinicians prefer to useleucocyte-depleted components.The clinical indications advanced for depleting bloodcomponents of leucocytes (leucodepletion) are as follows:(i) avoidance of febrile non-haemolytic transfusion reactions(FNHTRs); (ii) reduction ..

Leucocyte depletion of blood components -- guidelines of the Blood Transfusion Services of South Africa.