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Streptococcus agalactiae is an encapsulated Gram-positive coccus that colonises the gastrointestinal and genitourinary tracts. This organism belongs exclusively to Group B in Lancefield's grouping of Streptococcus species and therefore is referred to as Group B Streptococcus (GBS). Of the ten known serotypes, serotypes Ia and III account for most disease. The greatest burden of invasive GBS disease is seen in infants <3 months of age, although GBS can cause disease in adults and pregnant women. Disease manifesting in the first 6 days of life is referred to as early-onset disease (EOD), whereas late-onset disease (LOD) manifests from day 7 - 89 of life.

Preventing invasive Group B Streptococcus (GBS) disease in South African infants: Time for change