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Anaphylactic reactions caused by medications during general anesthesia rarely occur, but they can range from mild vasodilation to life-threatening cardiovascular events. Prophylactic antibiotics used to prevent postoperative infections are also one of the common agents that cause anaphylactic reactions during anesthesia. Therefore, in order to diagnose and prevent an anaphylactic reaction, it is necessary to first perform an antibiotic skin test (AST) before administering antibiotics to a patient. The specificity of the AST is known to be very high, greater than 90%. However, the results of the AST can differ according to the target drug, volume, and reagent concentration. We report a case of anaphylactic shock accompanied by cardiovascular collapse and bronchospasm immediately after administration of cefazedone, to which a negative preliminary AST was obtained, after induction of general anesthesia for laparoscopic cholecystectomy.

Anaphylaxis occurred immediately after prophylactic antibiotics injection with negative intradermal skin test during laparoscopic cholecystectomy