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In a search for new inhibitors of the TNF-alpha promoter activity, a new spiro-compound, designated oxaspirodion, was obtained as a mixture of four isomers from fermentations of the ascomycete Chaetomium subspirale. The structure was determined by a combination of spectroscopic techniques.

journal of antibiotics

Oxaspirodion, a New Inhibitor of Inducible TNF-.ALPHA. Expression from the Ascomycete Chaetomium subspirale Production, Isolation and Structure Elucidation