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groups of secondary metabolites, which are simultaneously produced by C. crocatus. Crocacin A, the main representative of the at first isolated group, is a complex N-acyl dipeptide, which effectively inhibits the growth of yeasts and fungi, caused by blocking the electron flow within the cytochrome bc1 segment (complex III) of the eukaryotic respiratory chain1,2). Another group, the chondramides A-D3,4) are new cyclo-depsipeptides structurally related to the sponge metabolite jaspamide/jasplakinolide5-7). They show only weak activity against yeasts, but are highly cytostatic for different cultured mammalian cell lines by interfering with the actin cytoskeleton8). Advanced analysis of crude extracts of C.

journal of antibiotics

Ajudazols, New Inhibitors of the Mitochondrial Electron Transport from Chondromyces crocatus: Production, Antimicrobial Activity and Mechanism of Action