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EI-2346, a novel interleukin-1beta converting enzyme (ICE) inhibitor, was isolated from the culture broths of Streptomyces sp. E-2346. EI-2346 selectively inhibited the human recombinant ICE activity with an IC50 value of 3.9 microM, without inhibiting elastase and cathepsin B. EI-2346 also inhibited mature interleukin-1beta secretion from THP-1 cells induced by LPS with an IC50 value of 5.2 microM.

journal of antibiotics

EI-2346, a Novel Interleukin-1.BETA. Converting Enzyme Inhibitor Produced by Streptomyces sp. E-2346: I. Taxonomy of Producing strain, Fermentation, Isolation, Physico-chemical Properties, and Biological Properties