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synthase have been discovered, including lipopeptides (pneumocandins and echinocandins), glycolipids (papulacandins) and terpenoids (enfumafungin, ascosteroside, ergokonin A, and arundifungin).1) Among these antifungal agents, caspofungin acetate (MK-0991), a semi-synthetic analogue of pneumocandins, has shown promising antifungal application in clinical trials, and has been launched as a parenteral antifungal agent.2) In the course of our continuing search for novel antifungal agents, we have isolated a novel antifungal agent Sch 601324 (1), from a fungal culture Chrysosporium sp. (Family: Onygenaceae). Sch 601324 was identified as a sterol sulfate, structurally related to arundifungin (2).3,4) In this paper, we describe the isolation and structure elucidation of 1 using high resolution ESMS and extensive NMR spectroscopic analysis. Fermentation studies were carried out in shake flasks. Stock cultures were maintained as frozen whole broths at

A New Antifungal Sterol Sulfate, Sch 601324, from Chrysosporium sp.