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Sir: Angiogenesis, the formation of new capillaries from preexisting vessels, is a prerequisite for many physiological processes, including embryonic development, wound healing, and female reproductive functions. Moreover, a number of pathological conditions such as cancer, rheumatoid arthritis, and other chronic inflammatory diseases are characterized by extensive angiogenesis.1-5) Recent studies have revealed that vascular endothelial growth factor (VEGF) plays a pivotal role in pathological situations that involve neovascularization as well as enhanced vascular permeability. Additionally, VEGF has been shown to strongly induce cell migration, proliferation, and tube formation with a unique specificity for endothelial cells.6,7) Consequently the concept that progression of various diseases may be halted by inhibiting endothelial cell functions has raised considerable interest.8) In a previous paper, we have already reported a novel fungal metabolite, epoxyquinol A (1), as an angiogenesis inhibitor.9) The continuous bioassy-guided purification led to a more potent angiogenesis inhibitor, epoxyquinol B (2), a unique diastereomer of 1 in respect to the structure, biosynthesis, and biological properties. In this communication, the isolation, structure, and biological activities of epoxyquinol B (2) are reported. The producing fungal strain was cultured in a 30-liter jar fermenter containing 18 liters of fermentation medium (glucose 1%, soluble starch 2%, soybean meal 1.5%, malt extract 0.5%, vegetable extract 10%, potato dextrose 2.5%,

Epoxyquinol B, a Fungal Metabolite with a Potent Antiangiogenic Activity.