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During our continuing screening for new bioactive metabolites from fungi we discovered recently hexacyclinol (1) as a novel, unusual, oligocyclic metabolite in cultures of the fungal strain Panus rudis HKI 0254. The strain was isolated from basidiospores of this fungus found on dead betula woods collected near Irkutsk (Sibiria, specimen herb. H, DORFELT, Sibiria 299). Panus rudis is of widespread occurrence throughout the world in many different ecotypes and has been reported to produce bioactive secondary metabolites1,2). The basidiomata of Panus rudis from the Sibirian source are growing singly or basal confluent to little tufts, excentric to central, stipitate, infundibuliform, with hazel-brown, strong tomentous pilei until 4.5cm in diameter; pilei and stipes with hairs until 2.5mm,

Hexacylinol, a New Antiproliferative Metabolite of Panus rudis HKI 0254.