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migrastatin isolate contained teleocidin-related compounds which display strong inhibitory activity against tumor cell migration. In this report, we describe the effects of teleocidin-free migrastatin on tumor cell migration and on the growth of several types of tumor cells. Whenthe original migrastatin sample was subjected to HPLC (Capcell Pak C18 column, 20X250mm) developing with 70% aq acetonitrile, a potent migration inhibitory activity was eluted in a fraction other than migrastatin, indicating that the migration inhibitory activity of our

Migrastatin, a Novel 14-Membered Ring Macrolide, Inhibits Anchorage-independent Growth of Human Small Cell Lung Carcinoma Ms-1 Cells.